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Polycyclic Aromatic Hydrocarbons in Maternal and Cord Blood Plasma

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Polycyclic Aromatic Hydrocarbons in Maternal and Cord Blood Plasma
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  POLYCYCLIC AROMATIC HYDROCARBONS IN MATERNAL AND CORD BLOOD PLASMA By Paula Gill Radmacher B.S., University of Louisville, 1973 M.S., University of Louisville, 1992 M.S.P.H., University of Louisville, 2000 A Dissertation Submitted to the Faculty of the Graduate School of the University of Louisville In Partial Fulfillment of the Requirements For the Degree of Doctor of Philosophy School of Public Health University of Louisville Louisville, KY May 2007   POLYCYCLIC AROMATIC HYDROCARBONS IN MATERNAL AND CORD BLOOD PLASMA By Paula Gill Radmacher B.S., University of Louisville, 1973 M.S., University of Louisville, 1992 M.S.P.H., University of Louisville, 2000 A Dissertation Approved on March 30, 2007 by the following Dissertation Committee:  ______________________________________ Stephen W. Looney, Ph.D., Dissertation Director  ______________________________________ Steven R. Myers, Ph.D. ___________________________________________ David H. Adamkin, M.D.  ___________________________________________ Susan B. Muldoon, Ph.D.  ___________________________________________ Shirley A. Wilkerson, M.D., Ph.D.  ii  DEDICATION This dissertation is dedicated to my family, beginning with my husband, Michael, who has always been my better half. He keeps me afloat in troubled waters and is truly my “first mate.” My daughters, Andrea and Katie, have always believed I could do it, even when I wasn’t so sure. Their support means more than I can express. I am also grateful to my late parents, Charles and Doris Gill, who firmly believed that education was the key to the future. iii  ACKNOWLEDGMENTS I would like to express my deep appreciation to my major professor, Dr. Stephen Looney, who persevered with me through distance, hurricane, and flood. His guidance and support were essential to the completion of this process. I would like to thank Dr. Steven Myers, who knew we could come up with a project (eventually) and opened his lab to me. I am also indebted to the other members of my committee, David Adamkin, MD, Susan Muldoon, Ph.D. and Shirley Wilkerson, MD, Ph.D., for their willingness to contribute their time and expertise to my education and growth. iv  ABSTRACT A PILOT STUDY OF POLYCYCLIC AROMATIC HYDROCARBONS IN MATERNAL AND CORD BLOOD PLASMA March 30, 2007 Polycyclic aromatic hydrocarbons (PAH) are chemicals generated from the incomplete combustion of organic materials, including tobacco smoke. Some PAH are known to be mutagenic and carcinogenic in humans, and of concern for the fetus when women smoke during pregnancy. Known consequences of smoking during pregnancy include low birth weight and preterm delivery. It is unknown if PAH are related to these outcomes. This pilot study was designed to measure concentrations of 3 PAH (anthracene, benzo(a)pyrene and 1-hydroxypyrene) in paired maternal and cord blood samples as well as any correlations between the two matrices. Plasma cotinine was used as a biomarker of tobacco exposure. Additionally, we asked if there is any relationship between the PAH concentrations and low birth weight or preterm delivery. Results showed that all 3 PAH could be found in maternal and cord plasma. Anthracene was consistently shown to be significantly elevated in cord plasma compared to maternal plasma in subgroups based on increasing cotinine concentrations. However, none of the compounds studied were correlated with either birth weight or gestational age. v

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Apr 28, 2018
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