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Effects of Cannabidiol on MK-801Induced Locomotor Sensitization in Mice

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Effects of Cannabidiol on MK-801Induced Locomotor Sensitization in Mice
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  Claremont Colleges Scholarship @ Claremont Scripps Senior TesesScripps Student Scholarship2012 Eects of Cannabidiol on MK-801-InducedLocomotor Sensitization in Mice Sara K. Cronin Scripps College Tis Open Access Senior Tesis is brought to you for free and open access by the Scripps Student Scholarship at Scholarship @ Claremont. It has beenaccepted for inclusion in Scripps Senior Teses by an authorized administrator of Scholarship @ Claremont. For more information, please contactscholarship@cuc.claremont.edu. Recommended Citation Cronin, Sara K., "Eects of Cannabidiol on MK-801-Induced Locomotor Sensitization in Mice" (2012). Scripps Senior Teses. Paper108.hp://scholarship.claremont.edu/scripps_theses/108    !""#$%& (" )*++*,-.-(/ (+ 01234526+.7$#. 8($(9(%(: ;#+&-%-<*%-(+ -+ 0-$# " #$%&'& ()%&%*+%, -. /0)0 1)2*'* /3)'44& 1255%6% To the Keck Science Department Of The Claremont Colleges In partial fulfillment of The degree of Bachelor of Arts /%*'2) #$%&'& '* 7%8)2&3'%*3% "4)'5 9:; 9<=9   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   2  -#,+."/+   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   3 0*+.'12/+3'* B0-+ *66%#$%&' %4 * 4%+'%K%#*'$ 4&#%*A *'6 "#&'&.%# C0&/A". %' 4&#%"$> 2  J9"0> >"*0 *66%#$%&' #&4$4 $=" ]'%$"6 !$*$"4 &9"0 ^I55 /%AA%&' %' $%." 4C"'$ &' $0"*$."'$ *'6 ^I8 /%AA%&' %' ="*A$= %'4-0*'#" VF"=*/ 1'$"0'*$%&'*AD 5MI5X2 ]C -'$%A $=" IU?M_4 60-+ *66%#$%&' G*4 $=&-+=$ $& /" * .&0*A KA*G %' #=*0*#$"0 V`%4"D 5MM5X 2  1$ G*4 $="' $=*$ $"#='&A&+%#*A *69*'#"4 %' "RC"0%."'$*A $"#='%a-"4 6%4#&9"0"6 $=*$ '&':=-.*' *'%.*A4 #&-A6 /" $*-+=$ $& C0"44 * A"9"0 $& /"+%' 4"AK:*6.%'%4$"0%'+ * 60-+ *'6 $=*$ $="> .*%'$*%'"6 $=" /"=*9%&0 2  <=-4D $=" %6"* $=*$ * 4-/4$*'#" #&-A6 /" %'="0"'$A> *66%#$%9"D .&0" &0 A"44 0"+*06A"44 &K &'"_4 .&0*A #=*0*#$"0 /"+*' $& =&A6 *.&'+ ."6%#*A C0*#$%$%&'"04 *'6 4#%"'$%4$4 Vb-A%"'D "$ *A *+  5MIIX 2  <&6*>D $=" 3."0%#*' )4>#=%*$0%# 344&#%*$%&' #&'4%6"04 *66%#$%&' * 6%4&06"0 *'6 A%4$4 %$ %' %$4 B%*+'&4$%# *'6 !$*$%4$%#*A @*'-*AD c&-0$= J6%$%&' V3)3D 5MMMX 2  `="' &'" %'+"4$4 * C4>#=&*#$%9" 60-+ 0"C"$%$%9"A> &0 %' "R#"44D %$ .*> A"*6 $& * '"-0&'*A *'6 '"-0&$0*'4.%$$"0 6>40"+-A*$%&' #*AA"6 4"'4%$%;*$%&' VS";%'*D 5MMPX2 Q&G"9"0D =&G 6& '"-0*A 4"'4%$%;*$%&' C0&#"44"4 %' $=" /0*%' 0"4-A$ %' *66%#$%&' *'6 *0" $="0" "KK"#$%9" ."$=&64 K&0 $0"*$."'$d <=" /0*%' %4 * 9"0> CA*4$%# &0+*' *'6 *6*C$4 $=0&-+=&-$ &'"_4 A%K" Vb-A%"'D "$ *A2D 5MIIX2 <="0"K&0"D %$ %4 $=&-+=$ $=*$ 4&." '"-0&*6*C$*$%&' $*Y"4 CA*#" %' $=" C0&#"44 &K *66%#$%&' *4 * 0"4-A$ &K 60-+ "RC&4-0"2 e'" Y'&G' G*> '"-0&*6*C$*$%&' .*'%K"4$4 %$4"AK %4 4"'4%$%;*$%&'2 !"'4%$%;*$%&' #*' /" 9%"G"6 *4 * .&6"A &K $=%4 '"-0&CA*4$%#%$> /"#*-4" %$ &##-04 %' 0"4C&'4" $& #=0&'%# &0 =%+= 6&4"4 &K * 60-+D A"*6%'+ $& *'$%#%C*$%&' &K 0"#"%9%'+ $=" 60-+ *'6 60-+:4""Y%'+ /"=*9%&0D * C="'&."'&' *A4& Y'&G' *4 f#0*9%'+g2
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